Safety and Efficacy of Transvaginal Natural Orifice Transluminal Endoscopic (vNOTES) Right Colectomy: A Systematic Review

Background/Objectives: We aim to provide pooled data on the safety and efficacy of Transvaginal Natural Orifice Transluminal Endoscopic (vNOTES) right colectomy.

Methods: This systematic review was conducted according to the Cochrane Handbook and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The primary endpoint was the overall complication rate. Quality assessment was based on the NHLBI quality assessment tools.

Results: Overall, six studies were included in this review. Overall morbidity rate was 21.9% (95% CI: 10.7–33.2%, p < 0.001), while intraoperative adverse events were noted in 19.9% (p < 0.001) of cases. Mean operation duration was 176.42 (p < 0.001) minutes. Overall hospital stay was 8.68 days (p = 0.002). 

Conclusions: Our analyses confirm the safety and efficacy of the approach. Given several study limitations, further large-scale and high-quality trials are required.