Primary neuroendocrine tumors of the breast: a case report

Primary neuroendocrine tumors (NETs) of the breast are a very rare type of tumors, originated from cells that make up the neuroendocrine system and produce peptides and amines. This type of tumor consists of a rare subtype of breast carcinoma, representing less than 1% of breast cancers, and occur mainly in postmenopausal women. NETs are graded as G1, G2 or as an invasive neuroendocrine carcinoma (NEC), small or large cells. Neuroendocrine carcinomas affect usually the gastrointestinal and the pulmonary system.

We present a rare case of an 88-years old- woman who presented with a mass in the right breast. The patient reported mild pain and localized tenderness throughout the day. The pathological identification revealed histologic sections of neoplastic mammary gland tissue exhibiting neuroendocrine immunomorphological features, consistent with well-differentiated grade.

This case highlights the rarity of primary neuroendocrine tumors of breast and the importance of their early diagnosis. Further studies and treatment strategies are needed to be made to discover the biological behavior of the tumor and more optimal therapies to maximize patient’s outcome.